Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model

Sucralose and saccharin-cyclamate mixture are considered as safe commercial artificial sweeteners with many health authorities instead of natural sugar. We aimed to reveal their effects on the physiological, immunological histological profiles. Mice were given sucralose (0.3 mg/ml) or (20 in drinking water for 8 16 weeks. Only caused a temporary significant increase blood glucose after weeks that was eliminated WBCs count decreased significantly administration. Aspartate aminotransferase (AST), Alanine (ALT), urea nitrogen (BUN) creatinine (Cr) recorded an at due two intake. Both induced interleukin (IL-) 6, tumor necrosis factor-alpha (TNF-?) circulating lipopolysaccharides (LPS) levels progress from 8th 16th post sugars, especially sucralose, severe damage kidney, liver, pancreas urinary bladder. Data indicated adverse effect mixture, consumption can cause inflammation Moreover, they may interrupt intestinal barriers leading LPS pro-inflammatory cytokine secretions.